Senescence in aging versus disease - Jan van Deursen, Ph.D., Mayo Clinic, Institut "Jožef Stefan", ponedeljek, 14. oktober 2019

The Universitätsmedizin Rostock, the project team HeLiXbyS and the Jožef Stefan Institute are inviting you to attend our keynote address by Jan van Deursen, Ph.D., Mayo Clinic on Senescence in aging versus disease.
Free Lunch will be provided for all attendees - please RSVP below.
Jan van Deursen, Ph.D., who is the chair of Mayo Clinic's Department of Biochemistry and Molecular Biology, received his Bachelor of Science in biology from the University of Nijmegen in the Netherlands, and continued at that institution to earn his master's degree and doctorate in molecular and cellular biology.One of Dr. van Deursen's notable discoveries originated from work published in 2004, when his group generated a new mouse strain defective in chromosome replication due to reduced cellular levels of the spindle assembly checkpoint protein BubR1. Dr. van Deursen's lab found that these mice aged much more quickly than normal—dying of old age before they were 1 year old. Whereas, normal mice live 2.5 to 3 years.In studying these mice, Dr. van Deursen's lab discovered that the animals showed rapid development of prematurely senescent cells — that is, cells that had turned on the p16 cell cycle inhibitor gene (INK4A), which made them stop dividing and begin to secrete inflammatory cytokines. To determine whether the senescent cells were not just indicators that the mice were aging rapidly but might actually be causing the rapid aging, fast-aging mice were crossed with mice that lacked the p16 gene.The team's work was published in Nature in November 2011 and captured the imagination of many in the scientific community as well as the public. Here, for the first time, was a clear demonstration of an intervention that dramatically delayed the deleterious effects of aging on multiple organs in a mouse model — an approach that, at least conceptually, could eventually be applied to humans.
In addition to generating a large number of exciting new projects in Dr. van Deursen's laboratory, this discovery has also prompted other scientists to begin studying the role of p16 and cellular senescence in mouse and human aging. As a concrete demonstration of the importance of this discovery, the journal Science selected the lab's Nature paper as one of the top 10 discoveries of the year in 2011.Dr. van Deursen has been recognized by numerous awards. He is the Vita Valley Professor of Cellular Senescence.

09h00 Keynote: Senescence in aging versus disease by Jan van Deursen, Ph.D., Mayo Clinic
10h00 Coffee break
10h15 Talk: bioinformatics of analysing cellular senescence & related processes by Joaquin Dopazo, Ph.D., Director Clinical Bioinformatics Area
11h15 Talks by bioinformatics/ machine learning experts:

Mitja Lustrek, Jožef Stefan Institute

Georg Fuellen/ Axel Kowald, Humboldt University

Peter Antal / Bence Bruncsics Budapest University of Technology and Economics

12h30 Free Lunch

ponedeljek, 14. oktober 2019, Institut "Jožef Stefan", Senescence in aging versus disease - Jan van Deursen, Ph.D., Mayo Clinic

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